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Literature summary for 2.3.1.74 extracted from

  • Lu, X.; Zhou, W.; Gao, F.
    Cloning, characterization and localization of CHS gene from blood orange, Citrus sinensis (L.) Osbeck cv. Ruby (2009), Mol. Biol. Rep., 36, 1983-1990.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CsCHS-bo, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, cloning and expression in Escherichia coli strain DH5alpha Citrus sinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 malonyl-CoA + 4-hydroxycinnamoyl-CoA Citrus sinensis the enzyme catalyzes the condensation of 4-hydroxycinnamoyl-CoA and three malonyl-CoA molecules to form the chalcone derivative, naringenin chalcone, which is the first committed step in the phenylpropanoid pathway of plants, leading to the biosynthesis of flavonoids, isoflavonoids, and anthocyanins 4 CoA + naringenin chalcone
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Organism

Organism UniProt Comment Textmining
Citrus sinensis
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cv. Ruby, gene CsCHS-bo
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 malonyl-CoA + 4-hydroxycinnamoyl-CoA the enzyme catalyzes the condensation of 4-hydroxycinnamoyl-CoA and three malonyl-CoA molecules to form the chalcone derivative, naringenin chalcone, which is the first committed step in the phenylpropanoid pathway of plants, leading to the biosynthesis of flavonoids, isoflavonoids, and anthocyanins Citrus sinensis 4 CoA + naringenin chalcone
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Subunits

Subunits Comment Organism
More the enzyme contains four CHS-specific conserved motifs and a CHS-family signature sequence GFGPG Citrus sinensis

Synonyms

Synonyms Comment Organism
chalcone synthase
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Citrus sinensis
CHS
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Citrus sinensis
More the enzyme is a member of the type III polyketide synthase superfamily Citrus sinensis

General Information

General Information Comment Organism
metabolism chalcone synthase is involved in the biosynthesis of anthocyanin Citrus sinensis