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Literature summary for 2.3.1.7 extracted from

  • Liu, J.; Killilea, D.W.; Ames, B.N.
    Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha -lipoic acid (2002), Proc. Natl. Acad. Sci. USA, 99, 1876-1881.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Fe2+
-
Rattus norvegicus
FeSO4
-
Rattus norvegicus
malondialdehyde
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km acetylcarnitine 1.25 mg/ml Rattus norvegicus
0.018
-
CoASH supplementation with R-alpha-lipoic acid Rattus norvegicus
0.019
-
acetylcarnitine supplementation with R-alpha-lipoic acid Rattus norvegicus
2
-
CoASH
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
Rattus norvegicus 5759
-
mitochondrion
-
Rattus norvegicus 5739
-
peroxisome
-
Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + carnitine Rattus norvegicus
-
O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine Oryctolagus cuniculus
-
O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine Columba sp.
-
O-acetylcarnitine + CoASH
-
r
acyl-CoA + carnitine Rattus norvegicus
-
acylcarnitine + CoASH
-
r
acyl-CoA + carnitine Oryctolagus cuniculus
-
acylcarnitine + CoASH
-
r
acyl-CoA + carnitine Columba sp.
-
acylcarnitine + CoASH
-
r
acylcarnitine + CoASH Rattus norvegicus
-
acyl-CoA + carnitine
-
r
acylcarnitine + CoASH Oryctolagus cuniculus
-
acyl-CoA + carnitine
-
r
acylcarnitine + CoASH Columba sp.
-
acyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Oryctolagus cuniculus
-
acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Columba sp.
-
acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Rattus norvegicus key mitochondrial enzyme for fuel utilization, essential functions are to regenerate CoA, which allows peroxisomal beta-oxidation to proceed, and to facilitate transport of acetyl moieties to mitochondria for oxidation acetyl-CoA + carnitine
-
r

Organism

Organism UniProt Comment Textmining
Columba sp.
-
pigeon
-
Columba sp.
-
commercial preparation, Sigma
-
Oryctolagus cuniculus
-
rabbit
-
Rattus norvegicus
-
rat
-
Rattus norvegicus
-
Fischer 344
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain
-
Oryctolagus cuniculus
-
breast muscle
-
Columba sp.
-
diaphragm
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-
muscle
-
Columba sp.
-
soleus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + carnitine
-
Rattus norvegicus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine
-
Oryctolagus cuniculus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine
-
Columba sp. O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Rattus norvegicus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Oryctolagus cuniculus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Columba sp. O-acetylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Rattus norvegicus acylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Oryctolagus cuniculus acylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Columba sp. acylcarnitine + CoASH
-
r
acylcarnitine + CoASH
-
Rattus norvegicus acyl-CoA + carnitine
-
r
acylcarnitine + CoASH
-
Oryctolagus cuniculus acyl-CoA + carnitine
-
r
acylcarnitine + CoASH
-
Columba sp. acyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH
-
Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Oryctolagus cuniculus acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Columba sp. acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Oryctolagus cuniculus acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH
-
Columba sp. acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH key mitochondrial enzyme for fuel utilization, essential functions are to regenerate CoA, which allows peroxisomal beta-oxidation to proceed, and to facilitate transport of acetyl moieties to mitochondria for oxidation Rattus norvegicus acetyl-CoA + carnitine
-
r