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Literature summary for 2.3.1.7 extracted from

  • Huckle, W.R.; Tamblyn, T.M.
    Purification and properties of carnitine acetyltransferases from bovine spermatozoa and heart (1983), Arch. Biochem. Biophys., 226, 94-110.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithio-bis(2-nitrobenzoic acid)
-
Bos taurus
5,5'-dithio-bis(2-nitrobenzoic acid)
-
Rattus norvegicus
acetyl-CoA
-
Bos taurus
acetyl-D-carnitine
-
Columba sp.
acetyl-L-(-)-carnitine
-
Bos taurus
acetylcarnitine
-
Bos taurus
acetylcarnitine
-
Rattus norvegicus
Ca2+
-
Bos taurus
CoASH
-
Bos taurus
D-carnitine
-
Bos taurus
D-carnitine
-
Columba sp.
L-(-)-carnitine
-
Bos taurus
N-ethylmaleimide
-
Bos taurus
N-ethylmaleimide
-
Rattus norvegicus
palmitoyl-CoA
-
Bos taurus
palmitoyl-CoA
-
Columba sp.
palmitoyl-CoA
-
Rattus norvegicus
Zn2+
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
CoASH
-
Bos taurus
0.012
-
acetyl-CoA sperm enzyme Bos taurus
0.014
-
propionyl-CoA
-
Bos taurus
0.015
-
acetyl-CoA
-
Bos taurus
0.02
-
acetyl-CoA heart enzyme Bos taurus
0.041
-
n-butyryl-CoA
-
Bos taurus
0.049
-
isobutyryl-CoA
-
Bos taurus
0.071
-
n-valeryl-CoA
-
Bos taurus
0.12
-
L-(-)-carnitine
-
Bos taurus
0.3
-
O-acetyl-L-carnitine heart enzyme Bos taurus
0.36
-
O-acetyl-L-carnitine sperm enzyme Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
microsome
-
Columba sp.
-
-
mitochondrion
-
Rattus norvegicus 5739
-
peroxisome
-
Rattus norvegicus 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
61000
-
heart enzyme, gel filtration, SDS-PAGE Bos taurus
62000
-
-
Rattus norvegicus
62000
-
sperm enzyme, gel filtration, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + carnitine Rattus norvegicus
-
O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine Bos taurus
-
O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine Ovis aries
-
O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine Columba sp.
-
O-acetylcarnitine + CoASH
-
r
acyl-CoA + carnitine Rattus norvegicus
-
acylcarnitine + CoASH
-
r
acyl-CoA + carnitine Bos taurus
-
acylcarnitine + CoASH
-
r
acyl-CoA + carnitine Ovis aries
-
acylcarnitine + CoASH
-
r
acyl-CoA + carnitine Columba sp.
-
acylcarnitine + CoASH
-
r
acylcarnitine + CoASH Rattus norvegicus
-
acyl-CoA + carnitine
-
r
acylcarnitine + CoASH Bos taurus
-
acyl-CoA + carnitine
-
r
acylcarnitine + CoASH Ovis aries
-
acyl-CoA + carnitine
-
r
acylcarnitine + CoASH Columba sp.
-
acyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Rattus norvegicus
-
acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Ovis aries
-
acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Columba sp.
-
acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH Bos taurus mitochondrial fatty acid transport acetyl-CoA + carnitine
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-
Bos taurus
-
beef
-
Bos taurus
-
Holstein bulls
-
Columba sp.
-
pigeon
-
Ovis aries
-
sheep
-
Ovis aries
-
ram
-
Rattus norvegicus
-
rat
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
heart
-
Bos taurus
-
heart
-
Columba sp.
-
liver
-
Rattus norvegicus
-
liver
-
Ovis aries
-
liver
-
Columba sp.
-
muscle
-
Rattus norvegicus
-
muscle
-
Ovis aries
-
muscle
-
Columba sp.
-
skeletal muscle
-
Rattus norvegicus
-
skeletal muscle
-
Ovis aries
-
spermatozoon
-
Rattus norvegicus
-
spermatozoon
-
Bos taurus
-
spermatozoon
-
Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
71
-
source heart Bos taurus
85
-
-
Rattus norvegicus
85
-
-
Columba sp.
85
-
source spermatozoon Bos taurus

Storage Stability

Storage Stability Organism
4°C, retains 60-80% activity over a period of several months Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + carnitine
-
Rattus norvegicus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine
-
Bos taurus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine
-
Ovis aries O-acetylcarnitine + CoASH
-
r
acetyl-CoA + carnitine
-
Columba sp. O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Rattus norvegicus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Bos taurus O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Ovis aries O-acetylcarnitine + CoASH
-
r
acetyl-CoA + L-(-)carnitine
-
Columba sp. O-acetylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Rattus norvegicus acylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Bos taurus acylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Ovis aries acylcarnitine + CoASH
-
r
acyl-CoA + carnitine
-
Columba sp. acylcarnitine + CoASH
-
r
acylcarnitine + CoASH
-
Rattus norvegicus acyl-CoA + carnitine
-
r
acylcarnitine + CoASH
-
Bos taurus acyl-CoA + carnitine
-
r
acylcarnitine + CoASH
-
Ovis aries acyl-CoA + carnitine
-
r
acylcarnitine + CoASH
-
Columba sp. acyl-CoA + carnitine
-
r
CoA + O-acetyl-L-carnitine
-
Bos taurus acetyl-CoA + L-carnitine
-
?
isobutyryl-CoA + carnitine
-
Bos taurus isobutyrylcarnitine + CoASH
-
r
isobutyrylcarnitine + CoASH
-
Bos taurus isobutyryl-CoA + carnitine
-
r
isovaleryl-CoA + carnitine
-
Bos taurus isovalerylcarnitine + CoASH
-
r
isovalerylcarnitine + CoASH
-
Bos taurus isovaleryl-CoA + carnitine
-
r
additional information D-carnitine is no substrate Bos taurus ?
-
?
additional information D-carnitine is no substrate Columba sp. ?
-
?
n-butyryl-CoA + carnitine
-
Rattus norvegicus n-butyrylcarnitine + CoASH
-
r
n-butyryl-CoA + carnitine
-
Bos taurus n-butyrylcarnitine + CoASH
-
r
n-butyrylcarnitine + CoASH
-
Rattus norvegicus n-butyryl-CoA + carnitine
-
r
n-butyrylcarnitine + CoASH
-
Bos taurus n-butyryl-CoA + carnitine
-
r
n-valeryl-CoA + carnitine
-
Bos taurus n-valerylcarnitine + CoASH
-
r
n-valerylcarnitine + CoASH
-
Bos taurus n-valeryl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH
-
Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Bos taurus acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Ovis aries acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Columba sp. acetyl-CoA + L-(-)carnitine
-
r
O-acetylcarnitine + CoASH
-
Rattus norvegicus acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH
-
Ovis aries acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH
-
Columba sp. acetyl-CoA + carnitine
-
r
O-acetylcarnitine + CoASH mitochondrial fatty acid transport Bos taurus acetyl-CoA + carnitine
-
r
octanoyl-CoA + carnitine
-
Rattus norvegicus octanoylcarnitine + CoASH
-
r
octanoyl-CoA + carnitine
-
Bos taurus octanoylcarnitine + CoASH
-
r
octanoylcarnitine + CoASH
-
Rattus norvegicus octanoyl-CoA + carnitine
-
r
octanoylcarnitine + CoASH
-
Bos taurus octanoyl-CoA + carnitine
-
r
propionyl-CoA + L-(-)carnitine
-
Rattus norvegicus propionylcarnitine + CoASH
-
r
propionyl-CoA + L-(-)carnitine
-
Bos taurus propionylcarnitine + CoASH
-
r
propionylcarnitine + CoASH
-
Rattus norvegicus propionyl-CoA + L-(-)carnitine
-
r
propionylcarnitine + CoASH
-
Bos taurus propionyl-CoA + L-(-)carnitine
-
r

Subunits

Subunits Comment Organism
monomer
-
Rattus norvegicus
monomer
-
Columba sp.
monomer 1 * 61000, heart enzyme, SDS-PAGE Bos taurus
monomer 1 * 62000, sperm enzyme, SDS-PAGE Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
CoASH sperm enzyme Bos taurus
0.016
-
palmitoyl-CoA
-
Bos taurus
0.021
-
CoASH heart enzyme Bos taurus
0.047
-
acetyl-CoA heart enzyme Bos taurus
0.052
-
acetyl-CoA sperm enzyme Bos taurus
0.25
-
L-(-)-carnitine heart enzyme Bos taurus
0.31
-
L-(-)-carnitine sperm enzyme Bos taurus
0.81
-
acetyl-L-(-)-carnitine heart enzyme Bos taurus
0.98
-
acetyl-L-(-)-carnitine sperm enzyme Bos taurus
1.1
-
D-carnitine
-
Bos taurus