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Literature summary for 2.3.1.67 extracted from

  • Ntzouvani, A.; Nomikos, T.; Petrogianni, M.; Dede, V.; Stamatakis, G.; Manios, Y.
    Effect of fortified milk on lyso-platelet-activating factor acetyltranferase and lipoprotein-associated phospholipase A2 in hypercholesterolemic adults (2013), Eur. J. Lipid Sci. Technol., 115, 142-152.
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Activating Compound

Activating Compound Comment Organism Structure
additional information 500 ml/day of low-fat milk fortified with phytosterols, linoleic and alpha linolenic acids, vitamin C, vitamin E, vitamin A, vitamin B6, vitamin B12, folic acid, magnesium and selenium has no effect on the enzyme activity in vivo Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information 500 ml/day of low-fat milk fortified with phytosterols, linoleic and alpha linolenic acids, vitamin C, vitamin E, vitamin A, vitamin B6, vitamin B12, folic acid, magnesium and selenium has no effect on the enzyme activity in vivo Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7L5N7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
lyso-PAF AT
-
 Homo sapiens
lyso-platelet-activating factor acetyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function a key metabolic enzyme of platelet-activating factor (PAF) syntesis, a potent inflammatory lipid mediator. Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a biologically active phospholipid implicated in physiological as well as pathological inflammatory processes such as atherogenesis. It affects several critical points of atherogenesis including thrombosis, inflammation and oxidation. Common risk factors for atherosclerosis, namely diabetes, cigarette smoking, oxidised low-density lipoprotein (LDL) and systemic inflammation, share elevated PAF and PAF-like lipids as a common feature Homo sapiens