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Literature summary for 2.3.1.67 extracted from

  • Sugatani, J.; Fukazawa, N.; Ujihara, K.; Yoshinari, K.; Abe, I.; Noguchi, H.; Miwa, M.
    Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation (2004), Int. Arch. Allergy Immunol., 134, 17-28.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(-)-epicatechin-3-O-gallate IC50: 0.072 mM Oryctolagus cuniculus
(-)-epigallocatechin IC50: 0.073 mM Oryctolagus cuniculus
(-)-epigallocatechin-3-O-gallate IC50: 0.046 mM Oryctolagus cuniculus
(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)
-
 Oryctolagus cuniculus
1,2,3,4,6-pentagalloyl-beta-D-glucose IC50: 0.026 mM Oryctolagus cuniculus
farnesyl gallate IC50: 0.066 mM Oryctolagus cuniculus
geranyl gallate IC50: 0.089 mM Oryctolagus cuniculus
n-dodecyl gallate IC50: 0.091 mM Oryctolagus cuniculus
procyanidin B-2,3,3'-di-O-gallate IC50: 0.031 mM Oryctolagus cuniculus
procyanidin B-5,3,3'-di-O-gallate IC50: 0.024 mM Oryctolagus cuniculus
theaflavin IC50: 0.032 mM Oryctolagus cuniculus
theaflavin-3'-O-gallate IC50: 0.039 mM Oryctolagus cuniculus
theaflavin-3,3'-di-O-gallate IC50: 0.028 mM Oryctolagus cuniculus
theaflavin-3-O-gallate IC50: 0.058 mM Oryctolagus cuniculus
theasinensin A IC50: 0.029 mM Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Oryctolagus cuniculus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.024
-
 IC50: 0.024 mM Oryctolagus cuniculus procyanidin B-5,3,3'-di-O-gallate
0.026
-
 IC50: 0.026 mM Oryctolagus cuniculus 1,2,3,4,6-pentagalloyl-beta-D-glucose
0.028
-
 IC50: 0.028 mM Oryctolagus cuniculus theaflavin-3,3'-di-O-gallate
0.029
-
 IC50: 0.029 mM Oryctolagus cuniculus (4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)
0.031
-
 IC50: 0.031 mM Oryctolagus cuniculus procyanidin B-2,3,3'-di-O-gallate
0.032
-
 IC50: 0.032 mM Oryctolagus cuniculus theaflavin
0.039
-
 IC50: 0.039 mM Oryctolagus cuniculus theaflavin-3'-O-gallate
0.046
-
 IC50: 0.046 mM Oryctolagus cuniculus (-)-epigallocatechin-3-O-gallate
0.058
-
 IC50: 0.058 mM Oryctolagus cuniculus theaflavin-3-O-gallate
0.066
-
 IC50: 0.066 mM Oryctolagus cuniculus farnesyl gallate
0.072
-
 IC50: 0.072 mM Oryctolagus cuniculus (-)-epicatechin-3-O-gallate
0.073
-
 IC50: 0.073 mM Oryctolagus cuniculus (-)-epigallocatechin
0.089
-
 IC50: 0.089 mM Oryctolagus cuniculus geranyl gallate
0.091
-
 IC50: 0.091 mM Oryctolagus cuniculus n-dodecyl gallate