Literature summary for 2.3.1.67 extracted from

Nagumo, S.; Fukuju, A.; Takayama, M.; Nagai, M.; Yanoshita, R.; Samejima, Y.
Inhibition of lysoPAF acetyltransferase activity by components of licorice root (1999), Biol. Pharm. Bull., 22, 1144-1146.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-methoxyphaseolidin	IC50: 0.048 mM	Rattus norvegicus
1-methoxyphaseolin	IC50: 0.057 mM	Rattus norvegicus
6,8-diprenylgenistein	IC50: 0.019 mM	Rattus norvegicus
licoricidin	IC50: 0.0077 mM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RBL-2H3 cell	mastocytoma cell, mucosal-type	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + alkyl-sn-glycero-3-phosphocholine	-	Rattus norvegicus	CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.9	-	assay at	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0077	-	IC50: 0.0077 mM	Rattus norvegicus	licoricidin
0.019	-	IC50: 0.019 mM	Rattus norvegicus	6,8-diprenylgenistein
0.048	-	IC50: 0.048 mM	Rattus norvegicus	1-methoxyphaseolidin
0.057	-	IC50: 0.057 mM	Rattus norvegicus	1-methoxyphaseolin

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Release 2023.1 (January 2023)