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Literature summary for 2.3.1.67 extracted from
- Inhibition of lysoPAF acetyltransferase activity by flavonoids (1996), Inflamm. Res., 45, 546-549.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-(1-Naphthylvinyl)pyridine | IC50: 0.043 mM | Rattus norvegicus |  |
| luteolin | IC50: 0.045 mM | Rattus norvegicus | |
| quercetin | IC50: 0.08 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| RBL-2H3 cell | mastocytoma cell, mucosal-type | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0021 | - |
A23187 stimulated cell | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine | - |
Rattus norvegicus | CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
assay at | Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.043 | - |
IC50: 0.043 mM | Rattus norvegicus | 4-(1-Naphthylvinyl)pyridine | |
| 0.045 | - |
IC50: 0.045 mM | Rattus norvegicus | luteolin | |
| 0.08 | - |
IC50: 0.08 mM | Rattus norvegicus | quercetin | |
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Release 2023.1 (January 2023)
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