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Literature summary for 2.3.1.62 extracted from
- An accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases (2019), Biochim. Biophys. Acta, 1864, 1053-1060 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene LCLAT1, recombinant expression in HEK-293 cells | Mus musculus |
| gene LPCAT1, functional recombinant expression in HEK-293 cells | Mus musculus |
| gene LPCAT1, functional recombinant expression in HEK-293 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 2-acyl-sn-glycero-3-phosphatidylcholine | Mus musculus | - |
CoA + 1,2-diacyl-sn-glycero-3-phosphatidylcholine | - |
? |  |
| acyl-CoA + 2-acyl-sn-lysophosphatidylcholine | Mus musculus | - |
CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 2-acyl-sn-lysophosphatidylcholine | Homo sapiens | - |
CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| additional information | Mus musculus | LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin | ? | - |
- |
|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8NF37 | - |
- |
| Mus musculus | Q3TFD2 | - |
- |
| Mus musculus | Q3UN02 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293A cell | - |
Mus musculus | - |
| HEK-293A cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 2-acyl-sn-glycero-3-phosphatidylcholine | - |
Mus musculus | CoA + 1,2-diacyl-sn-glycero-3-phosphatidylcholine | - |
? | |
| acyl-CoA + 2-acyl-sn-lysophosphatidylcholine | - |
Mus musculus | CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| acyl-CoA + 2-acyl-sn-lysophosphatidylcholine | - |
Homo sapiens | CoA + 1,2-diacyl-sn-lysophosphatidylcholine | - |
? | |
| additional information | LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin | Mus musculus | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn2 positions of palmitoyl-LPC | Mus musculus | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LPCAT1 introduces palmitic acid both at the sn-1 and sn2 positions of palmitoyl-lysophosphatidylcholine (LPC). sn-1-palmitoyl LPC appears to have a slightly higher affinity for LPCAT1 than sn-2-palmitoyl LPC, while sn-2-palmitoyl LPC has a higher turnover rate | Homo sapiens | ? | - |
- |
|
| additional information | development and evaluation of an accurate and versatile method for determining the acyl group-introducing position of lysophospholipid acyltransferases, overview. Positional specificity of the hydroxyl group of the glycerol backbone (sn-2 or sn-1) at which LPLATs introduce a fatty acid. LYCAT introduces stearic acid predominantly at the sn-1 position of LPG. The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin | Mus musculus | ? | - |
- |
|
| palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine | reaction of EC 2.3.1.23 | Mus musculus | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine | reaction of EC 2.3.1.23 | Homo sapiens | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| palmitoyl-CoA + 2-palmitoyl-lysophosphatidylcholine | - |
Homo sapiens | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| palmitoyl-CoA + 2-palmitoyl-sn-lysophosphatidylcholine | - |
Mus musculus | CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine | - |
? | |
| stearoyl-CoA + 2-oleoyl-sn-glycero-3-phosphatidylcholine | preferred substrate | Mus musculus | CoA + 1-stearoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acyl-CoA:lysocardiolipin acyltransferase 2 | - |
Mus musculus |
| AGPAT8 | - |
Mus musculus |
| Alcat1 | - |
Mus musculus |
| Lclat1 | - |
Mus musculus |
| LPC acyltransferase | - |
Mus musculus |
| LPC acyltransferase | - |
Homo sapiens |
| LPCAT1 | - |
Mus musculus |
| LPCAT1 | - |
Homo sapiens |
| LPLAT | - |
Mus musculus |
| LPLAT | - |
Homo sapiens |
| LYCAT | - |
Mus musculus |
| lysophospholipid acyltransferase | - |
Mus musculus |
| lysophospholipid acyltransferase | - |
Homo sapiens |
| More | cf. EC 2.3.1.23 | Mus musculus |
| More | cf. EC 2.3.1.23 | Homo sapiens |
| More | cf. EC 2.3.1.51 and 2.3.1.23 | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Homo sapiens |
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