Literature summary for 2.3.1.61 extracted from

Chen, B.; Long, Q.; Zhao, Y.; Wu, Y.; Ge, S.; Wang, P.; Yang, C.G.; Chi, Y.; Song, B.; Yang, S.
Sulfone-based probes unraveled dihydrolipoamide S-succinyltransferase as an unprecedented target in phytopathogens (2019), J. Agric. Food Chem., 67, 6962-6969 .

Search for more literature for 2.3.1.61

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 cells	Xanthomonas oryzae pv. oryzae

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(ethanesulfonyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(4-fluorophenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(ethanesulfonyl)-5-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(ethanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(methanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole	-	Xanthomonas citri
2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole	-	Xanthomonas oryzae pv. oryzae
additional information	no activity with 5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)phenyl)-1,3,4-oxadiazol-2-ol	Xanthomonas citri
additional information	no activity with 5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)phenyl)-1,3,4-oxadiazol-2-ol	Xanthomonas oryzae pv. oryzae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	Xanthomonas citri	-	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	Xanthomonas oryzae pv. oryzae	-	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	Xanthomonas oryzae pv. oryzae PXO99A	-	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	Xanthomonas citri 29-1	-	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?

Organism

Organism	UniProt	Comment	Textmining
Xanthomonas citri	-	-	-
Xanthomonas citri 29-1	-	-	-
Xanthomonas oryzae pv. oryzae	-	-	-
Xanthomonas oryzae pv. oryzae PXO99A	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
HisTrap column chromatography	Xanthomonas oryzae pv. oryzae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	-	Xanthomonas citri	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	-	Xanthomonas oryzae pv. oryzae	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	-	Xanthomonas oryzae pv. oryzae PXO99A	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	-	Xanthomonas citri 29-1	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?

Subunits

Subunits	Comment	Organism
?	x * 45000, SDS-PAGE	Xanthomonas citri
?	x * 45000, SDS-PAGE	Xanthomonas oryzae pv. oryzae
?	x * 42100, calculated from amino acid sequence	Xanthomonas oryzae pv. oryzae

Synonyms

Synonyms	Comment	Organism
dihydrolipoamide S-succinyltransferase	-	Xanthomonas citri
dihydrolipoamide S-succinyltransferase	-	Xanthomonas oryzae pv. oryzae
DLST	-	Xanthomonas citri
DLST	-	Xanthomonas oryzae pv. oryzae
SucB	-	Xanthomonas citri
SucB	-	Xanthomonas oryzae pv. oryzae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00351	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(4-fluorophenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
0.00358	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
0.00358	-	at pH 7.2 and 28°C	Xanthomonas oryzae pv. oryzae	2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole
0.00399	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
0.00551	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(methanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
0.0068	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(2,4-dichloro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(ethanesulfonyl)-1,3,4-oxadiazole
0.00706	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(ethanesulfonyl)-5-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
0.00795	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(ethanesulfonyl)-5-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
0.00859	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(4-fluorophenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
0.01263	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(ethanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
0.01394	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(ethanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
0.0156	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(methanesulfonyl)-5-(4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-1,3,4-oxadiazole
0.01753	-	at pH 7.2 and 28°	Xanthomonas oryzae pv. oryzae	2-(4-fluoro-3-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)-5-(methanesulfonyl)-1,3,4-oxadiazole
0.01753	-	at pH 7.2 and 28°C	Xanthomonas citri	2-(methylsulfonyl)-5-(4-fluoro-3-((prop-2-yn-1-yloxy)methyl)-phenyl)-1,3,4-oxadiazole

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Release 2023.1 (January 2023)