Literature summary for 2.3.1.61 extracted from

Heggermont, W.A.; Papageorgiou, A.P.; Quaegebeur, A.; Deckx, S.; Carai, P.; Verhesen, W.; Eelen, G.; Schoors, S.; van Leeuwen, R.; Alekseev, S.; Elzenaar, I.; Vinckier, S.; Pokreisz, P.; Walravens, A.S.; Gijsbers, R.; Van Den Haute, C.; Nickel, A.; Schroen, B.; van Bilsen, M.; Janssens, S.; Maack, C.; Pinto, Y.; Carmeliet, P.; Heymans, S.
Inhibition of microRNA-146a and overexpression of its target dihydrolipoyl succinyltransferase protect against pressure overload-induced cardiac hypertrophy and dysfunction (2017), Circulation, 136, 747-761 .

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	Mus musculus	-	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?

Organism	UniProt	Comment	Textmining
Mus musculus	Q9D2G2	-	-

Source Tissue	Comment	Organism	Textmining
heart	-	Mus musculus	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine	-	Mus musculus	CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine	-	?

Synonyms	Comment	Organism
dihydrolipolyl succinyltransferase	-	Mus musculus
DLST	-	Mus musculus
E2 subcomponent of the alpha-ketoglutarate dehydrogenase complex	-	Mus musculus

Organism	Comment	Expression
Mus musculus	enzyme protein levels significantly decrease in wild type mice after 4 weeks of angiotensin-II or 6 weeks of transversal aortic constriction. Enzyme levels significantly decrease in microRNA-146a wild-type mice on angiotensin-II administration	down

General Information	Comment	Organism
physiological function	enzyme overexpression in wild type mice protects against cardiac hypertrophy and dysfunction in vivo	Mus musculus