Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | nuclei of cholinergic neurons | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28329 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 82000, calculated from sequence | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | acute exposure to amyloid Abeta1-42 results in increased association of ChAT with chromatin and formation of ChAT aggregates in nuclei. Abeta1-42 -exposure increases ChAT association with gene promoters and introns. The Abeta1-42 -induced ChAT aggregates colocalize with special AT-rich binding protein 1 (SATB1), which anchors DNA to scaffolding/matrix attachment regions (S/MARs). Both ChAT and SATB proteins associate with synapse and cell stress genes. After Abeta1-42 -exposure, both SATB1 and ChAT are enriched at the same S/MAR on the APP gene, with ChAT expression attenuating an increase in an isoform-specific APP mRNA transcript | Homo sapiens |