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Literature summary for 2.3.1.6 extracted from

  • Kumar, A.; Lana, E.; Kumar, R.; Lithner, C.U.; Darreh-Shori, T.
    Soluble Abeta42 acts as allosteric activator of the core cholinergic enzyme choline acetyltransferase (2018), Front. Mol. Neurosci., 11, 327 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
Abeta42 peptide acts as allosteric enhancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P28329
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-

Source Tissue

Source Tissue Comment Organism Textmining
cerebrospinal fluid
-
 Homo sapiens
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General Information

General Information Comment Organism
physiological function both soluble amyloid Abeta40 and Abeta42 enhance the catalytic efficiency of ChAT byabout 21% and 26% at physiological concentration ranges found in cerebrospinal fluid. Activation of ChAT by Abeta is highly specific. Abeta42 exhibits an EC50 of activation at 10fold lower concentrations compared to Abeta40. The activation is persistent even in the presence of a physiological Abeta40/42 mixture ratio, expected in human cerebrospinal fluid Homo sapiens