Literature summary for 2.3.1.59 extracted from

Benveniste, R.; Davies, J.
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria (1973), Proc. Natl. Acad. Sci. USA, 70, 2276-2280.

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Application

Application	Comment	Organism
analysis	rapid analysis of antibiotic concentration in serum	Streptomyces kanamyceticus
analysis	rapid analysis of antibiotic concentration in serum	Streptomyces spectabilis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Streptomyces spectabilis	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Streptomyces spectabilis	modification of antibiotics	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces kanamyceticus	-	-	-
Streptomyces spectabilis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + gentamicin C1	-	Streptomyces spectabilis	CoA + N2'-acetylgentamicin C1	-	?
acetyl-CoA + gentamicin C1a	-	Streptomyces kanamyceticus	CoA + N2'-acetylgentamicin C1a	-	?
acetyl-CoA + gentamicin C1a	acetylates 2'-amino group of hexose moiety	Streptomyces spectabilis	CoA + N2'-acetylgentamicin C1a	-	?
acetyl-CoA + kanamycin B	-	Streptomyces spectabilis	CoA + N2-acetylkanamycin B	-	?
acetyl-CoA + kanamycin C	-	Streptomyces spectabilis	CoA + N2'-acetylkanamycin C	-	?
acetyl-CoA + paromomycin	-	Streptomyces spectabilis	CoA + N2'-acetylparomomycin	-	?
additional information	-	Streptomyces spectabilis	?	-	?
additional information	modification of antibiotics	Streptomyces spectabilis	?	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.3	-	-	Streptomyces spectabilis

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Release 2023.1 (January 2023)