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Literature summary for 2.3.1.57 extracted from

  • Hu, L.I.; Filippova, E.V.; Dang, J.; Pshenychnyi, S.; Ruan, J.; Kiryukhina, O.; Anderson, W.F.; Kuhn, M.L.; Wolfe, A.J.
    The spermidine acetyltransferase SpeG regulates transcription of the small RNA rprA (2018), PLoS ONE, 13, e0207563 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)-magic cells Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Escherichia coli
-
 CoA + N1-acetylspermidine
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A951
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex S200 gel filtration Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Escherichia coli CoA + N1-acetylspermidine
-
 ?
additional information the enzyme does not acetylate RcsB in vitro Escherichia coli ?
-
-

Synonyms

Synonyms Comment Organism
SpeG
-
 Escherichia coli
spermidine acetyltransferase
-
 Escherichia coli
spermidine N-acetyltransferase
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism the enzyme acetylates and thus neutralizes toxic polyamines Escherichia coli
physiological function the enzyme is a modulator of Escherichia coli transcription through its ability to interact with the transcription factor RcsB. The enzyme interacts with the DNA-binding domain of RcsB and this interaction might be responsible for enzyme-dependent inhibition of RcsB-dependent small RNA rprA transcription Escherichia coli