Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | Homo sapiens | - |
CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | Homo sapiens | - |
CoA + N1-acetylspermine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BEL-7402 cell | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
SMMC-7721 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | - |
Homo sapiens | CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | - |
Homo sapiens | CoA + N1-acetylspermine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Homo sapiens |
SSAT | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | protein expression of the enzyme is significantly up-regulated in hepatocellular carcinoma and colorectal cancer cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | depletion of polyamines by the enzyme significantly inhibits cell proliferation, migration and invasion through AKT/GSK3beta/beta-catenin signaling pathway in hepatocellular carcinoma and colorectal cancer cells. The enzyme inhibits cell colony formation and proliferation rate in hepatocellular and colorectal carcinoma cells | Homo sapiens |