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Literature summary for 2.3.1.57 extracted from

  • Wang, C.; Ruan, P.; Zhao, Y.; Li, X.; Wang, J.; Wu, X.; Liu, T.; Wang, S.; Hou, J.; Li, W.; Li, Q.; Li, J.; Dai, F.; Fang, D.; Wang, C.; Xie, S.
    Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/beta-catenin signaling pathways in hepatocellular and colorectal carcinoma cells (2017), Oncotarget, 8, 1092-1109 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Homo sapiens
-
CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermine Homo sapiens
-
CoA + N1-acetylspermine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEL-7402 cell
-
Homo sapiens
-
colorectal cancer cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
hepatoma cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
SMMC-7721 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
Homo sapiens CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermine
-
Homo sapiens CoA + N1-acetylspermine
-
?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase
-
Homo sapiens
SSAT
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens protein expression of the enzyme is significantly up-regulated in hepatocellular carcinoma and colorectal cancer cells up

General Information

General Information Comment Organism
physiological function depletion of polyamines by the enzyme significantly inhibits cell proliferation, migration and invasion through AKT/GSK3beta/beta-catenin signaling pathway in hepatocellular carcinoma and colorectal cancer cells. The enzyme inhibits cell colony formation and proliferation rate in hepatocellular and colorectal carcinoma cells Homo sapiens