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Literature summary for 2.3.1.57 extracted from

  • Yuan, F.; Zhang, L.; Cao, Y.; Gao, W.; Zhao, C.; Fang, Y.; Zahedi, K.; Soleimani, M.; Lu, X.; Fang, Z.; Yang, Q.
    Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis (2018), Metab. Clin. Exp., 85, 298-304 .
    View publication on PubMed
Search for more literature for 2.3.1.57

Activating Compound

Activating Compound Comment Organism Structure
N1, N11-diethylnorspermine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Mus musculus
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Mus musculus
-
 CoA + N1-acetylspermine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P48026
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Mus musculus CoA + N1-acetylspermine
-
 ?

Synonyms

Synonyms Comment Organism
SAT1
-
 Mus musculus
spermidine-spermine N1-acetyltransferase
-
 Mus musculus
spermidine/spermine N1-acetyltransferase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus both cold and beta3-adrenergic receptor agonist CL-316,243 increase the expression of the enzyme in inguinal white adipose tissue and brown adipose tissue up

General Information

General Information Comment Organism
malfunction enzyme knockout mice develop late-onset obesity on a high-fat diet with impaired cold-induced beige adipocyte biogenesis and energy expenditure Mus musculus
physiological function enzyme activation plays a key role in cold and beta3-adrenergic receptor agonist-induced beige adipocyte biogenesis and low-grade inflammation. Enzyme activation enhances hydrogen peroxide production in adipocytes. Adipose enzyme regulates beige adipocyte thermogenesis Mus musculus