Literature summary for 2.3.1.57 extracted from

Squassina, A.; Manchia, M.; Chillotti, C.; Deiana, V.; Congiu, D.; Paribello, F.; Roncada, P.; Soggiu, A.; Piras, C.; Urbani, A.; Robertson, G.S.; Keddy, P.; Turecki, G.; Rouleau, G.A.; Alda, M.; Del Zompo, M.
Differential effect of lithium on spermidine/spermine N1-acetyltransferase expression in suicidal behaviour (2013), Int. J. Neuropsychopharmacol., 16, 2209-2218.

Search for more literature for 2.3.1.57

Cloned(Commentary)

Cloned (Comment)	Organism
gene sat1, quantitative one-step real-time PCR enzyme expression analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21673	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B lymphoblastoid cell	-	Homo sapiens	-
brain	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SAT1	-	Homo sapiens
spermidine/spermine N1-acetyltransferase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	lithium induces enzyme expression in low and high risk groups for suicide commitment as well as in controls, but it has no effect in suicide completers. Differences in lithium-induced increase in SAT1 mRNA levels, overview	up

General Information

General Information	Comment	Organism
malfunction	the enzyme is underexpressed in brains from suicide victims compared to controls	Homo sapiens
physiological function	polyamines (agmatine, putrescine, spermine and spermidine) are ubiquitous molecules involved in cell growth and differentiation. They modulate neurotransmission and are responsible for the polyamine mediated stress response, a cascade of molecular events transiently activated by acute stress stimuli. Chronic stress can lead to a hyperactivation of the polyamine system, ultimately leading to cell growth inhibition and cell death. Spermidine/spermine N1-acetyltranserare 1 is the key regulator of cellular polyamine content and is involved in the catabolism of spermidine and spermine, a key step in the maintenance of polyamine homeostasis	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)