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Literature summary for 2.3.1.57 extracted from

  • Tucker, J.M.; Murphy, J.T.; Kisiel, N.; Diegelman, P.; Barbour, K.W.; Davis, C.; Medda, M.; Alhonen, L.; Janne, J.; Kramer, D.L.; Porter, C.W.; Berger, F.G.
    Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase (2005), Cancer Res., 65, 5390-5398.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information crossing of ApcMin/+ MIN mice with enzyme-overexpressing transgenic mice results in mice with a 3-6fold higher development of adenomas in the small intestine and colon compared to wild-type mice, crossing of ApcMin/+ MIN mice with SSAT-knockout mice reduces the development of adenomas by 75% in the small intestine Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Mus musculus
-
 CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine Mus musculus
-
 CoA + N1-acetylspermine
-
 ?
additional information Mus musculus the enzyme is involved in intestinal tumorigenesis in ApcMin/+ MIN mice, enzyme is involved in catabolism of polyamines, activation of the enzyme in vivo results in suppression of tumor outgrowth in a mouse prostate cancer model ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
 Mus musculus CoA + N1-acetylspermidine
-
 ?
acetyl-CoA + spermine
-
 Mus musculus CoA + N1-acetylspermine
-
 ?
additional information the enzyme is involved in intestinal tumorigenesis in ApcMin/+ MIN mice, enzyme is involved in catabolism of polyamines, activation of the enzyme in vivo results in suppression of tumor outgrowth in a mouse prostate cancer model Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase
-
 Mus musculus
SSAT
-
 Mus musculus