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Literature summary for 2.3.1.56 extracted from

  • Boteju, L.W.; Hanna, P.E.
    Bioactivation of N-hydroxy-2-acetylaminofluorenes by N,O-acyltransferase: substituent effects on covalent binding to DNA (1993), Carcinogenesis, 14, 1651-1657.
    View publication on PubMed
Search for more literature for 2.3.1.56

Application

Application Comment Organism
medicine bioactivation of N-hydroxy-2-acetylaminofluorenes by N,O-acytransfer resulting in mutagenic and carcinogenic compounds, DNA adduct formation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens
0.0075
-
 7-ethyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-acetyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
-
 Homo sapiens 7-acetyl-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
 ?
7-bromo-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
-
 Homo sapiens 7-bromo-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
 ?
7-ethoxy-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
-
 Homo sapiens 7-ethoxy-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
 ?
7-ethyl-N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
-
 Homo sapiens 7-ethyl-N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
 ?
additional information 7-substituted-N-hydroxy-2-acetylamino fluorenes form adducts with DNA, which is inhibited by addition of ascorbic acid, 4-(2-biphenyl)-2-hydroxytetronic acid, and partly by N-tert-butyl-alpha-phenylnitrone, triethylphosphite, potassium O-ethylxanthate, thiourea, and N-acetylmethionine, not in case of 7-acetyl-N-hydroxy-2-acetylamino fluorene Homo sapiens ?
-
 ?
N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene
-
 Homo sapiens N-hydroxy-2-aminofluorene + N-acetoxy-4-aminoazobenzene
-
 ?