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Literature summary for 2.3.1.50 extracted from

  • Perry, D.K.; Carton, J.; Shah, A.K.; Meredith, F.; Uhlinger, D.J.; Hannun, Y.A.
    Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis (2000), J. Biol. Chem., 275, 9078-9084.
    View publication on PubMed
Search for more literature for 2.3.1.50

Activating Compound

Activating Compound Comment Organism Structure
etoposide
-
 Homo sapiens
etoposide activates enzyme activity, but decreases mRNA level, time-dependent Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
RT-PCR from mRNA of Molt-4 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information time-dependent degradation of enzyme mRNA by etoposide, activation of enzyme activity on protein level, time-dependent; time-dependent degradation of enzyme mRNA by etoposide, activation of enzyme activity on protein level, time-dependent Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Homo sapiens
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ir
palmitoyl-CoA + L-serine Homo sapiens first step of biosynthesis of sphingolipid bases CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine Homo sapiens rate-limiting enzyme in synthesis of sphingolipids CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine Homo sapiens initial step of de novo ceramide biosynthesis CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens O15269 gene hLCB1
-
Homo sapiens O15270 gene hLCB2
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture leukemia Molt-4 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
 Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine
-
 Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ir
palmitoyl-CoA + L-serine first step of biosynthesis of sphingolipid bases Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine rate-limiting enzyme in synthesis of sphingolipids Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine initial step of de novo ceramide biosynthesis Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
 assay at Homo sapiens