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Literature summary for 2.3.1.50 extracted from

  • Hanada, K.; Nishijima, M.; Fujita, T.; Kobayashi, S.
    Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant (2000), Biochem. Pharmacol., 59, 1211-1216.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
beta-chloro-L-alanine cytotoxic, irreversible Cricetulus griseus
L-Cycloserine cytotoxic, irreversible Cricetulus griseus
myriocin i.e. sphingofungin B; strong inhibition, reversible by sphingosine Cricetulus griseus
thermozymocidin i.e. ISP-1; strong inhibition, reversible by sphingosine Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Cricetulus griseus
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
 genetically corrected revertant strain LY-B/cLCB1 of deficient mutant LY-B
-
Cricetulus griseus
-
 mutant defective strain LY-B
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary cell culture Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
 Cricetulus griseus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?