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Literature summary for 2.3.1.50 extracted from

  • Merrill, A.H.; Williams, R.D.
    Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain (1984), J. Lipid Res., 25, 185-188.
    View publication on PubMed
Search for more literature for 2.3.1.50

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Rattus norvegicus first step of biosynthesis of sphingolipid bases CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information specificity Rattus norvegicus ?
-
 ?
palmitoyl-CoA + L-serine palmitoyl-CoA is the preferred substrate Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine activities are greatest with palmitoyl-CoA and palmitelaidoyl-CoA, followed by fully saturated homologs, activity considerably diminishes as the alkyl-chain length increases or decreases, or with the presence of a cis-double bond Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine first step of biosynthesis of sphingolipid bases Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
 assay at Rattus norvegicus