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Literature summary for 2.3.1.50 extracted from

  • Holleran, W.M.; Williams, M.L.; Gao, W.N.; Elias, P.M.
    Serine-palmitoyl transferase activity in cultured human keratinocytes (1990), J. Lipid Res., 31, 1655-1661.
    View publication on PubMed
Search for more literature for 2.3.1.50

Inhibitors

Inhibitors Comment Organism Structure
beta-chloro-L-alanine
-
 Homo sapiens
L-Cycloserine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
 L-serine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Homo sapiens rate-limiting enzyme in synthesis of sphingolipids CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte neonatal Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00027
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information increasing the acyl-CoA chain length above C16 by 1 or 2 carbons is less detrimental to activity than similar decrements in chain length Homo sapiens ?
-
 ?
palmitoyl-CoA + L-serine palmitoyl-CoA is used in preference to other saturated or unsaturated acyl-CoA substrates Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine rate-limiting enzyme in synthesis of sphingolipids Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.2
-
-
 Homo sapiens