Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.5 extracted from

  • Turijan-Espinoza, E.; Salazar-Gonzalez, R.A.; Uresti-Rivera, E.E.; Hernandez-Hernandez, G.E.; Ortega-Juarez, M.; Milan, R.; Portales-Perez, D.
    A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity (2018), Acta Pharm. Sin. B, 8, 188-199 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.5

Activating Compound

Activating Compound Comment Organism Structure
additional information the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. NAT2 metabolizing capacity increases significantly when sirtuins are inhibited with nicotinamide Homo sapiens
additional information the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. No effect on NAT1 activity is observed when sirtuins are inhibited with different concentrations of nicotinamide for 24 h Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol; the activity of NAT1 in cell culture does not change when cells are stimulated with different concentrations of sirtuin agonist resveratrol, compared to cells in culture medium. No effect on NAT1 activity is observed when sirtuins are inhibited with different concentrations of nicotinamide for 24 h Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245 isoform NAT2
-
Homo sapiens P18440
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminobenzoate
-
 Homo sapiens CoA + N-acetyl-4-aminobenzoate
-
 ?
acetyl-CoA + isoniazid
-
 Homo sapiens CoA + N-acetylisoniazid
-
 ?

Synonyms

Synonyms Comment Organism
NAT2
-
 Homo sapiens