Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.5 extracted from

  • Duval, R.; Xu, X.; Bui, L.C.; Mathieu, C.; Petit, E.; Cariou, K.; Dodd, R.H.; Dupret, J.M.; Rodrigues-Lima, F.
    Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens (2016), Oncotarget, 7, 8688-8699.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Benzyl isothiocyanate
-
Homo sapiens
additional information not inhibited by N-methylphenethylamine. GSH or dithiothreitol are unable to reactivate significantly inhibited isoform NAT1 Homo sapiens
phenethyl isothiocyanate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His-select nickel resin column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + 4-aminobenzoic acid
-
Homo sapiens 4-nitrophenol + N-acetyl-4-aminobenzoate
-
?

Synonyms

Synonyms Comment Organism
NAT1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.007
-
at pH 7.5 and 37°C Homo sapiens Benzyl isothiocyanate
0.015
-
at pH 7.5 and 37°C Homo sapiens phenethyl isothiocyanate