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Literature summary for 2.3.1.5 extracted from

  • Laurieri, N.; Kawamura, A.; Westwood, I.M.; Varney, A.; Morris, E.; Russell, A.J.; Stanley, L.A.; Sim, E.
    Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding (2014), BMC Pharmacol. Toxicol., 15, 68.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.5

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)CodonPlus-RIL cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by N-(3-(3,5-dimethylphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzenesulfonamide Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA resin column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminobenzoate 6% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-aminobenzoate
-
 ?
acetyl-CoA + 4-aminoveratrole 57% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-aminoveratrole
-
 ?
acetyl-CoA + 4-bromoaniline 72% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-bromoaniline
-
 ?
acetyl-CoA + 4-chloroaniline 71% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-chloroaniline
-
 ?
acetyl-CoA + 4-hexyloxyaniline 51% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-hexyloxyaniline
-
 ?
acetyl-CoA + 4-iodoaniline 65% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-iodoaniline
-
 ?
acetyl-CoA + 4-methoxyaniline 9% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-methoxyaniline
-
 ?
acetyl-CoA + 4-phenoxyaniline 62% activity compared to hydralazine Homo sapiens CoA + N-acetyl-4-phenoxyaniline
-
 ?
acetyl-CoA + 5-aminosalicylate 64% activity compared to hydralazine Homo sapiens CoA + N-acetyl-5-aminosalicylate
-
 ?
acetyl-CoA + hydralazine 100% activity Homo sapiens CoA + N-acetylhydralazine
-
 ?
acetyl-CoA + isoniazid 62% activity compared to hydralazine Homo sapiens CoA + N-acetylisoniazid
-
 ?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate 3% activity compared to hydralazine Homo sapiens CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
 ?
acetyl-CoA + sulfamethazine 46% activity compared to hydralazine Homo sapiens CoA + N-acetylsulfamethazine
-
 ?

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase type 2
-
 Homo sapiens
NAT2
-
 Homo sapiens