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Literature summary for 2.3.1.5 extracted from

  • Minchin, R.F.; Butcher, N.J.
    The role of lysine(100) in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: implications for other acetyltransferases (2015), Biochem. Pharmacol., 94, 195-202.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K100E the mutation significantly increases the Ka value for acetyl-CoA without changing the Kb value for the acetyl acceptor 4-aminobenzoate Homo sapiens
K100L the mutation significantly increases the Ka value for acetyl-CoA without changing the Kb value for the acetyl acceptor 4-aminobenzoate Homo sapiens
K100R the mutation significantly decreases the Ka value for acetyl-CoA without changing the Kb value for the acetyl acceptor 4-aminobenzoate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-dephospho-acetyl-CoA + 4-aminobenzoate
-
Homo sapiens 3'-dephospho-CoA + N-acetyl-4-aminobenzoate
-
?
4-nitrophenyl acetate + 4-aminobenzoate
-
Homo sapiens 4-nitrophenol + N-acetyl-4-aminobenzoate
-
?
acetyl-CoA + 4-aminobenzoate
-
Homo sapiens CoA + N-acetyl-4-aminobenzoate
-
?

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 1
-
Homo sapiens
NAT1
-
Homo sapiens