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Literature summary for 2.3.1.5 extracted from

  • Kukongviriyapan, V.; Phromsopha, N.; Tassaneeyakul, W.; Kukongviriyapan, U.; Sripa, B.; Hahnvajanawong, V.; Bhudhisawasdi, V.
    Inhibitory effects of polyphenolic compounds on human arylamine N-acetyltransferase 1 and 2 (2006), Xenobiotica, 36, 15-28.
    View publication on PubMed
Search for more literature for 2.3.1.5

Activating Compound

Activating Compound Comment Organism Structure
glycyrrhizic acid slightly activates isozyme NAT1 Homo sapiens

Application

Application Comment Organism
drug development inhibitors of NAT enzymes may be valuable as chemopreventive agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin-3-O-gallate EGCG, non-competitive Homo sapiens
caffeic acid non-competitive Homo sapiens
curcumin non-competitive Homo sapiens
esculetin
-
 Homo sapiens
ferulic acid
-
 Homo sapiens
gallic acid
-
 Homo sapiens
genistein
-
 Homo sapiens
kaemferol non-competitive; non-competitive Homo sapiens
additional information inhibitory potency of flavonoids on isozyme NAT1, no inhibition by curcumin, silymarin, and scopoletin, overview; inhibitory potency of flavonoids on isozyme NAT2, no inhibition by (–)epigallocatechin gallate, gallic acid, caffeic acid, and ferulic acid, overview Homo sapiens
quercetin non-competitive; non-competitive Homo sapiens
scopoletin
-
 Homo sapiens
silymarin
-
 Homo sapiens
taxifolin
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme NAT1 Homo sapiens 5829
-
cytosol isozyme NAT2 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an arylamine Homo sapiens NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines CoA + an N-acetylarylamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P18440 isozyme NAT1; isozyme NAT1
-
Homo sapiens P11245 isozyme NAT2; isozyme NAT2
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by subcellular fractionation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cholangiocarcinoma cell isozyme NAT1 Homo sapiens
-
KMBC cell a cholangiocarcinoma cell line, isozyme NAT1 Homo sapiens
-
liver isozyme NAT1 Homo sapiens
-
liver isozyme NAT2 Homo sapiens
-
additional information no isozyme NAT2 activity in cholangiocarcinoma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminobenzoic acid isozyme NAT1 Homo sapiens CoA + N-acetyl-4-aminobenzoic acid
-
 ?
acetyl-CoA + an arylamine NATs are important enzymes involved in the metabolic activation of aromatic and heterocyclic amines Homo sapiens CoA + an N-acetylarylamine
-
 ?
acetyl-CoA + an arylamine
-
 Homo sapiens CoA + an N-acetylarylamine
-
 ?
acetyl-CoA + sulfamethazine isozyme NAT2 Homo sapiens CoA + N-acetyl-sulfamethazine
-
 ?

Synonyms

Synonyms Comment Organism
NAT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, isozyme NAT1 Homo sapiens
additional information
-
 additional information inhibition kinetics, isozyme NAT2 Homo sapiens
0.01
-
 quercetin isozyme NAT2 Homo sapiens
0.0486
-
 quercetin isozyme NAT1 Homo sapiens