Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-methoxypsoralen | i.e. 5-MOP, activates the enzyme at 50 mM and the further metabolism of the product of the enzyme catalytic reaction 2-acetylaminofluorene in the stomach and colon | Rattus norvegicus | |
5-methoxypsoralen | i.e. 5-MOP, activates the enzyme at 50 mM in Colo 205 cells, inhibitory at lower dosage of 0.05-0.5 mM in Colo 205 cells and at 0.5-0.25 mM in SC-M1 cells, concentrations of 5-25 mM have no effect in Colo 205 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-methoxypsoralen | i.e. 5-MOP, activates the enzyme at 50 mM in Colo 205 cells, inhibitory at lower dosage of 0.05-0.5 mM, concentrations of 5-25 mM have no effect in Colo 205 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-aminofluorene | Homo sapiens | - |
CoA + 2-acetylaminofluorene | - |
? | |
acetyl-CoA + 2-aminofluorene | Rattus norvegicus | - |
CoA + 2-acetylaminofluorene | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Colo-205 cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
colon | high activity | Rattus norvegicus | - |
SC-M1 cell | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
stomach | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-aminofluorene | - |
Homo sapiens | CoA + 2-acetylaminofluorene | - |
? | |
acetyl-CoA + 2-aminofluorene | - |
Rattus norvegicus | CoA + 2-acetylaminofluorene | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAT | - |
Homo sapiens |
NAT | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens | |
acetyl-CoA | - |
Rattus norvegicus |