Cloned (Comment) | Organism |
---|---|
NAT1 and NAT2, expressed in Escherichia coli XA90 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C223G | NAT2, enzymatically active, markedly reduced in vitro stability | Homo sapiens |
C44G | NAT2, enzymatically active, markedly reduced in vitro stability | Homo sapiens |
C68G | NAT2, no enzymatic activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.5 | - |
sulfamethazine | isozyme NAT1 | Homo sapiens | |
45 | - |
procainamide | isozyme NAT1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-aminofluorene | N-acetyltransferase 2 | Homo sapiens | CoA + 2-acetylaminofluorene | - |
? | |
acetyl-CoA + 4-aminosalicylic acid | - |
Homo sapiens | CoA + 4-acetylamino-2-hydroxybenzoate | - |
? | |
acetyl-CoA + procainamide | N-acetyltransferase 2 | Homo sapiens | CoA + N-acetylprocainamide | - |
? | |
acetyl-CoA + sulfamethazine | N-acetyltransferase 2 | Homo sapiens | CoA + N-4-acetylsulfamethazine | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
t1/2: 35 h NAT2 wild-type, 3.5 h Cys44Gly-mutant, 0.5 h Cys223Gly-mutant | Homo sapiens |