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Literature summary for 2.3.1.5 extracted from

  • Andres, H.H.; Kolb, H.J.; Schreiber, R.J.; Weiss, L.
    Characterization of the active site, substrate specificity and kinetic properties of acetyl-CoA:arylamine N-acetyltransferase from pigeon liver (1983), Biochim. Biophys. Acta, 746, 193-201.
    View publication on PubMed
Search for more literature for 2.3.1.5

Inhibitors

Inhibitors Comment Organism Structure
3',5'-ADP kinetics Columba sp.
AMP kinetics Columba sp.
coenzyme A
-
 Columba sp.
DTNB partly reversible by dithioerythritol Columba sp.
iodoacetamide
-
 Columba sp.
iodoacetic acid
-
 Columba sp.
p-chloromercuribenzoate
-
 Columba sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic data of various acetyl donors with 4-nitroaniline or aniline as acceptor amine and of various acceptor amines with acetyl-CoA as donor Columba sp.

Organism

Organism UniProt Comment Textmining
Anas sp.
-
 duck
-
Columba sp.
-
 pigeon
-
Meleagris gallopavo
-
-
-
Oncorhynchus mykiss
-
 trout
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine mechanism and characterization of active site Columba sp.
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Meleagris gallopavo
-
liver
-
 Oncorhynchus mykiss
-
liver
-
 Anas sp.
-
liver
-
 Columba sp.
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Columba sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Meleagris gallopavo ?
-
 ?
additional information
-
 Oncorhynchus mykiss ?
-
 ?
additional information
-
 Anas sp. ?
-
 ?
additional information the reaction proceeds via a covalent acetyl-enzyme intermediate Columba sp. ?
-
 ?
additional information no substrate: o-nitroaniline Columba sp. ?
-
 ?
additional information 4-nitroacetanilide, 4-nitrophenylacetate can replace acetyl-CoA Columba sp. ?
-
 ?
additional information no substrate: 2-amino-6-nitropyridine Columba sp. ?
-
 ?
p-nitroacetanilide + aniline
-
 Columba sp. p-nitroaniline + acetanilide
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 pH-optimum depends on the nature of the acetyl acceptor amine Meleagris gallopavo
additional information
-
 pH-optimum depends on the nature of the acetyl acceptor amine Oncorhynchus mykiss
additional information
-
 pH-optimum depends on the nature of the acetyl acceptor amine Anas sp.
additional information
-
 pH-optimum depends on the nature of the acetyl acceptor amine Columba sp.
5.9
-
 4-nitroaniline Columba sp.
6.4
-
 1,2-phenylenediamine Columba sp.
7
-
 1,3-phenylenediamine Columba sp.
7.9
-
 1,4-phenylenediamine Columba sp.
9.1
-
 benzylamine Columba sp.