Literature summary for 2.3.1.48 extracted from

Zhang, P.; Liu, Y.; Jin, C.; Zhang, M.; Tang, F.; Zhou, Y.
Histone acetyltransferase GCN5 regulates osteogenic differentiation of mesenchymal stem cells by inhibiting NF-kappaB (2016), J. Bone Miner. Res., 31, 391-402 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mesenchymal stem cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Gcn5	general control nonderepressible 5	Mus musculus
HAT	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	the enzyme expression is decreased significantly in the bone tissue sections of ovariectomized mice or aged mice	down

General Information

General Information	Comment	Organism
malfunction	knockdown of the enzyme inhibits differentiation of mesenchymal stem cells into osteoblast cells. The impaired osteogenic differentiation by enzyme knockdown is blocked by inhibition of nuclear factor kappaB	Mus musculus
metabolism	the enzyme regulates osteogenic differentiation of mesenchymal stem cells by inhibiting nuclear factor kappaB. The enzyme represses nuclear factor kappa B-dependent transcription and inhibits the nuclear factor kappaB signaling pathway	Mus musculus

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Release 2023.1 (January 2023)