Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.48 extracted from

  • Thorsheim, K.; Persson, A.; Siegbahn, A.; Tykesson, E.; Westergren-Thorsson, G.; Mani, K.; Ellervik, U.
    Disubstituted naphthyl beta-D-xylopyranosides Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition (2016), Glycoconj. J., 33, 245-257 .
    View publication on PubMed
Search for more literature for 2.3.1.48

Inhibitors

Inhibitors Comment Organism Structure
2-(6,7-dihydroxynaphthyl) beta-D-xylopyranoside less than 50% residual activity at 0.1 mM Homo sapiens
2-(6,7-dimethoxynaphthyl) beta-D-xylopyranoside about 80% residual activity at 0.1 mM Homo sapiens
2-(6-hydroxy-7-methoxy-naphthyl) beta-D-xylopyranoside less than 50% residual activity at 0.1 mM Homo sapiens
2-(7-hydroxy-6-methoxy-naphthyl) beta-D-xylopyranoside about 55% residual activity at 0.1 mM Homo sapiens
anacardic acid
-
 Homo sapiens
curcumin
-
 Homo sapiens
garcinol
-
 Homo sapiens
additional information the enzyme is not inhibited by xyloside-primed GAG chains Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [histone H3]-L-lysine Homo sapiens
-
 CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCD-1095Sk cell
-
 Homo sapiens
-
HCC-70 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [histone H3]-L-lysine
-
 Homo sapiens CoA + [histone H3]-N6-acetyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
HAT
-
 Homo sapiens