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Literature summary for 2.3.1.48 extracted from

  • Yin, S.; Jiang, X.; Jiang, H.; Gao, Q.; Wang, F.; Fan, S.; Khan, T.; Jabeen, N.; Khan, M.; Ali, A.; Xu, P.; Pandita, T.; Fan, H.; Zhang, Y.; Shi, Q.
    Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels (2017), Development, 144, 2165-2174 .
No PubMed abstract available
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [histone H4]-L-lysine16 Mus musculus
-
 CoA + [histone H4]-N6-acetyl-L-lysine16
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D1P2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell
-
 Mus musculus
-
oocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [histone H4]-L-lysine16
-
 Mus musculus CoA + [histone H4]-N6-acetyl-L-lysine16
-
 ?

Synonyms

Synonyms Comment Organism
K (lysine) acetyltransferase 8
-
 Mus musculus
KAT8
-
 Mus musculus
Mof
-
 Mus musculus
MYST1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus during oocyte development, there is about 5fold increase between 14 days and full-grown germinal vesicle stage oocytes up

General Information

General Information Comment Organism
malfunction oocyte enzyme deletion results in female infertility, with follicle development failure in the secondary and preantral follicle stages. Enzyme deletion results in abnormal heterochromatin configurations in oocytes. Granulosa cell-specific deletion of the enzyme does not affect follicle development or female fertility Mus musculus
physiological function the enzyme has an essential function in oogenesis and is essential for female fertility by regulating antioxidant gene expression. The enzyme directly regulates antioxidant gene expression in oocytes Mus musculus