Cloned (Comment) | Organism |
---|---|
gene KAT6B, genotyping in small cell lung cancer cell lines, recombinant expression of GST- and FLAG-tagged KAT6B histone acetyltransferase domain in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gene KAT6B mutational screening. shRNA-mediated depletion of KAT6B induces an increase in Rb phosphorylation, and KAT6B shRNA-depleted cells also show diminished expression of Brahma | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Homo sapiens | acetylation of Lys23 | CoA + acetylhistone H3 | - |
? | |
additional information | Homo sapiens | Brahma is a target of enzyme Kat6B | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8WYB5 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant GST- and FLAG-tagged KAT6B histone acetyltransferase domain from Escherichia coli by affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
DMS-114 cell | - |
Homo sapiens | - |
NCI-H1048 cell | - |
Homo sapiens | - |
NCI-H1672 cell | - |
Homo sapiens | - |
NCI-H1963 cell | - |
Homo sapiens | - |
NCI-H2029 cell | - |
Homo sapiens | - |
NCI-H2171 cell | - |
Homo sapiens | - |
NCI-H740 cell | - |
Homo sapiens | - |
NCI-N417 cell | - |
Homo sapiens | - |
small cell lung cancer cell | - |
Homo sapiens | - |
WI-38 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | acetylation of Lys23 | Homo sapiens | CoA + acetylhistone H3 | - |
? | |
additional information | Brahma is a target of enzyme Kat6B | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
KAT6B | - |
Homo sapiens |
Morf | - |
Homo sapiens |
MYST4 | - |
Homo sapiens |
tumor suppressor histone H3 lysine 23 acetyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the MYST family | Homo sapiens |
malfunction | small cell lung cancer cells are deficient of the histone acetyltransferase KAT6B. The depletion of KAT6B expression enhances cancer growth, while its restoration induces tumor suppressor-like features. Enzyme deletion or inhibition confers sensitivity to irinotecan, causes diminished expression of Brahma, and induces an increase in Rb phosphorylation | Homo sapiens |
physiological function | enzyme KAT6B has tumor suppressorlike properties in cancer cells and exerts its tumor-inhibitory role through a defined type of histone H3 Lys23 acetyltransferase activity | Homo sapiens |