Cloned (Comment) | Organism |
---|---|
expression in insect cells | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
C732W | mutation abolishes the binding to histone H3 | Arabidopsis thaliana |
C740W | mutation abolishes the binding to histone H3 | Arabidopsis thaliana |
D924A | mutation in conserved residues in the histone acetyltransferase domain, abolishes the in vitro acetyltransferase activity | Arabidopsis thaliana |
E451Stop | mutation results in the silencing of 35S-NPTII but not the RD29A-LUC transgene | Arabidopsis thaliana |
E941Q | mutation in conserved residues in the histone acetyltransferase domain, abolishes the in vitro acetyltransferase activity | Arabidopsis thaliana |
M942A | mutation in conserved residues in the histone acetyltransferase domain, diminishes the in vitro acetyltransferase activity | Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | F4IXE7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Arabidopsis thaliana | CoA + acetylhistone H3 | residues K14, K18, and K23 of H3 are acetylated by domain C1 of isoform Idm1 in vitro | ? |
Subunits | Comment | Organism |
---|---|---|
More | isoform IDM1 is predicted to have a metal-binding domain, a plant homeo finger domain and an N-acetyltransferase domain. The plant homeo finger of IDM1 specifically binds the N-terminal tail of histone H3 and the binding is inhibited by H3K4 di- or trimethylation | Arabidopsis thaliana |
Synonyms | Comment | Organism |
---|---|---|
At3g14980 | - |
Arabidopsis thaliana |
Idm1 | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform IDM1is a regulator of DNA demethylation. IDM1 is required for preventing DNA hypermethylation of highly homologous multicopy genes and other repetitive sequences that are normally targeted for active DNA demethylation by Repressor of Silencing 1 and related 5-methylcytosine DNA glycosylases. IDM1 binds methylated DNA at chromatin sites lacking histone H3K4 di- or trimethylation and acetylates H3 to create a chromatin environment permissible for 5-methylcytosine DNA glycosylases to function | Arabidopsis thaliana |