Literature summary for 2.3.1.48 extracted from

Xue-Franzen, Y.; Johnsson, A.; Brodin, D.; Henriksson, J.; Buerglin, T.R.; Wright, A.P.
Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles (2010), BMC Genomics, 11, 200.

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Organism

Organism	UniProt	Comment	Textmining
Lachancea kluyveri	-	-	-
Saccharomyces cerevisiae	-	-	-

Synonyms

Synonyms	Comment	Organism
Gcn5	-	Saccharomyces cerevisiae
Gcn5	-	Lachancea kluyveri

General Information

General Information	Comment	Organism
physiological function	transcriptional coactivator gcn5 gene replacement mutants show a mild growth deficiency. Gcn5 is required for adaptation to stresses mediated by KCl and CaCl2, calcoflour white, MnCl2 and caffeine. The histone acetyltransferase activity of Gcn5 is required for its role in stress response	Lachancea kluyveri
physiological function	transcriptional coactivytor gcn5 gene replacement mutants show a mild growth deficiency. Gcn5 is required for adaptation to stresses mediated by KCl and CaCl2, calcoflour white, MnCl2 and caffeine. The histone acetyltransferase activity of Gcn5 is required for its role in stress response. Gcn5-dependent KCl response genes include membrane transporter VMR1 and heat-shock-response gene SSA4. The FLO8 gene, which encodes a transcriptional regulator, is up-regulated in the mutant. During KCl stress adaptation, Gcn5 shows a tendency for redistribution from short genes to the transcribed regions of long genes	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)