Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of p300 increases the basal and UV-induced matrix metalloproteinase MMP-1 promoter activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anacardic acid | a p300HAT inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Homo sapiens | - |
CoA + acetylhistone H3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | primary dermal | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p300 histone acetyltransferase | - |
Homo sapiens |
p300HAT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | down-regulation of p300 by siRNA prevents UV-induced matrix metalloproteinase MMP-1 expression and inhibits UV-enhanced phosphorylation of H2AX, p53 level, and acetyl-H3 | down |
Homo sapiens | UV irradiation of cultured human dermal fibroblasts induces matrix metalloproteinase MMP-1 expression and increases the level of phosphorylation of H2AX, p53 and the acetylation of histone H3 | up |