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Literature summary for 2.3.1.48 extracted from
- HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by geminin (2010), Mol. Cell, 37, 57-66.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | coexpression of HBO1 and Jade-1 increases histone acetylation and MCM complex loading, loading, whereas overexpression of HBO1 alone does not | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of mutant HATG485. Coexpression of HBO1 and Jade-1 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G485 | a HBO1 mutant, which contains a mutation of an invariant glycine in the histone acetyltransferase domain that abolishes enzymatic activity | Homo sapiens |
| additional information | a histone acetylase-defective mutant of HBO1 bound at origins is unable to load the MCM complex, also overexpression of the Set8 histone H4 tail-binding domain specifically inhibits MCM loading | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| geminin | a Cdt1 repressor, inhibits HBO1 acetylase activity in a a Cdt1-dependent manner in the context of a Cdt1-HBO1 complex, and it associates with origins and inhibits H4 acetylation and licensing in vivo, but geminin does not block the interaction of Cdt1 with HBO1 in vitro or Cdt1-dependent recruitment of HBO1 to replication origins in vivo | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H4 | Homo sapiens | HBO1 is an H4-specific histone acetylase, and is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is essential for DNA licensing of replication origins, where it controls H4 acetylation at the origins. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition | CoA + acetylhistone H4 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | H4 acetylation at origins by HBO1 is cell-cycle regulated, with maximal activity at the G1/S transition | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H4 | - |
Homo sapiens | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + histone H4 | HBO1 is an H4-specific histone acetylase, and is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is essential for DNA licensing of replication origins, where it controls H4 acetylation at the origins. H4 acetylation at origins is cell-cycle regulated, with maximal activity at the G1/S transition | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HAT | - |
Homo sapiens |
| HBO1 | - |
Homo sapiens |
| histone acetylase | - |
Homo sapiens |
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