Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-tert-butyl-5-(dodecylthio)isothiazol-3(2H)-one-1-oxide | - |
Homo sapiens | |
2-tert-butyl-5-chloroisothiazol-3(2H)-one 1-oxide | - |
Homo sapiens | |
4,5-dichloro-2-ethylisothiazol-3(2H)-one | - |
Homo sapiens | |
4,5-dichloro-2-ethylisothiazol-3(2H)-one-1-oxide | - |
Homo sapiens | |
5-chloro-2-ethyl-4-methylisothiazol-3(2H)-one | - |
Homo sapiens | |
5-chloro-2-ethyl-4-methylisothiazol-3(2H)-one-1-oxide | - |
Homo sapiens | |
5-chloro-2-ethylisothiazol-3(2H)-one | - |
Homo sapiens | |
5-chloro-2-ethylisothiazol-3(2H)-one-1-oxide | - |
Homo sapiens | |
methyl 3-(4,5-dichloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate | - |
Homo sapiens | |
methyl 3-(4,5-dichloro-3-oxoisothiazol-2(3H)-yl)propanoate | - |
Homo sapiens | |
methyl 3-(5-chloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate | - |
Homo sapiens | |
methyl 3-(5-chloro-3-oxoisothiazol-2(3H)-yl)propanoate | - |
Homo sapiens | |
methyl 3-(5-chloro-4-methyl-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate | - |
Homo sapiens | |
methyl 3-(5-chloro-4-methyl-3-oxoisothiazol-2(3H)-yl)propanoate | - |
Homo sapiens | |
methyl 3-[4-chloro-5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl]propanoate | - |
Homo sapiens | |
methyl 3-[5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl] propanoate | - |
Homo sapiens | |
additional information | inhibitory potencies of isothiazolones and isothiazolone-1-oxides on PCAF and growth inhibition of Hep-G2 cancer cells, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p300/CBP associated factor | - |
Homo sapiens |
PCAF | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0018 | - |
- |
Homo sapiens | methyl 3-(5-chloro-3-oxoisothiazol-2(3H)-yl)propanoate | |
0.0024 | - |
- |
Homo sapiens | 4,5-dichloro-2-ethylisothiazol-3(2H)-one | |
0.0026 | - |
- |
Homo sapiens | methyl 3-(4,5-dichloro-3-oxoisothiazol-2(3H)-yl)propanoate | |
0.003 | - |
- |
Homo sapiens | 5-chloro-2-ethylisothiazol-3(2H)-one | |
0.0056 | - |
- |
Homo sapiens | methyl 3-(5-chloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate | |
0.01 | - |
above | Homo sapiens | 5-chloro-2-ethyl-4-methylisothiazol-3(2H)-one | |
0.01 | - |
above | Homo sapiens | methyl 3-(5-chloro-4-methyl-3-oxoisothiazol-2(3H)-yl)propanoate | |
0.01 | - |
above | Homo sapiens | 5-chloro-2-ethylisothiazol-3(2H)-one-1-oxide | |
0.01 | - |
above | Homo sapiens | 4,5-dichloro-2-ethylisothiazol-3(2H)-one-1-oxide | |
0.01 | - |
above | Homo sapiens | 5-chloro-2-ethyl-4-methylisothiazol-3(2H)-one-1-oxide | |
0.01 | - |
above | Homo sapiens | methyl 3-(4,5-dichloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate | |
0.01 | - |
above | Homo sapiens | methyl 3-(5-chloro-4-methyl-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate | |
0.01 | - |
above | Homo sapiens | 2-tert-butyl-5-chloroisothiazol-3(2H)-one 1-oxide | |
0.01 | - |
above | Homo sapiens | 2-tert-butyl-5-(dodecylthio)isothiazol-3(2H)-one-1-oxide | |
0.01 | - |
above | Homo sapiens | methyl 3-[5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl] propanoate | |
0.01 | - |
above | Homo sapiens | methyl 3-[4-chloro-5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl]propanoate |