Protein Variants | Comment | Organism |
---|---|---|
additional information | hematopoietic deficiency in MOZ-DELTAC mice occurs in terms of decreased numbers of blood cells, significantly reduced hematopoietic progenitors and HSC and an increase in nucleated erythrocytes, phenotype, overview. When MOZ-deficient fetal liver cells are transplanted into irradiated mice, recipient mice do not develop a reconstituted hematopoietic system, even when excess numbers of fetal liver cells are transplanted | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Mus musculus | - |
CoA + acetylhistone H3 | - |
? | |
additional information | Mus musculus | MOZ specifically interacts and associates with transcription factors such as AML1, PU.1, p53, Runx2 and NF-kappaB, functioning as their transcriptional coactivator and cooperatively activating target gene transcription | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroid cell | - |
Mus musculus | - |
myeloid progenitor cell | - |
Mus musculus | - |
pre-B-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Mus musculus | CoA + acetylhistone H3 | - |
? | |
additional information | MOZ specifically interacts and associates with transcription factors such as AML1, PU.1, p53, Runx2 and NF-kappaB, functioning as their transcriptional coactivator and cooperatively activating target gene transcription | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Mus musculus |
monocytic leukemia zinc finger protein | - |
Mus musculus |
More | MOZ, i.e. monocytic leukemia zinc finger protein, is a Myst, i.e. MOZ, Ybf2 (Sas3), Sas2, Tip60, type histone acetyltransferase, HAT | Mus musculus |
MOZ | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | MOZ generates fusion genes, such as MOZ-TIF2, MOZ-CBP and MOZ-p300, in acute myeloid leukemia by chromosomal translocation leading to repressed differentiation, hyper-proliferation, and self-renewal of myeloid progenitors through deregulation of MOZ-regulated target gene expression. Roles of MOZ and MOZ fusion genes in normal and malignant hematopoiesis, mechanism, overview | Mus musculus |
physiological function | histone acetylation is one of the major epigenetic mechanisms to regulate gene expression. MOZ is essential for the generation and maintenance of hematopoietic stem cells and for the appropriate development of myeloid, erythroid and B-lineage cell progenitors. MOZ is also required for self-renewal of hematopoietic stem cells | Mus musculus |