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Literature summary for 2.3.1.48 extracted from

  • Katsumoto, T.; Yoshida, N.; Kitabayashi, I.
    Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis (2008), Cancer Sci., 99, 1523-1527.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information hematopoietic deficiency in MOZ-DELTAC mice occurs in terms of decreased numbers of blood cells, significantly reduced hematopoietic progenitors and HSC and an increase in nucleated erythrocytes, phenotype, overview. When MOZ-deficient fetal liver cells are transplanted into irradiated mice, recipient mice do not develop a reconstituted hematopoietic system, even when excess numbers of fetal liver cells are transplanted Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Mus musculus
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CoA + acetylhistone H3
-
?
additional information Mus musculus MOZ specifically interacts and associates with transcription factors such as AML1, PU.1, p53, Runx2 and NF-kappaB, functioning as their transcriptional coactivator and cooperatively activating target gene transcription ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythroid cell
-
Mus musculus
-
myeloid progenitor cell
-
Mus musculus
-
pre-B-lymphocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3
-
Mus musculus CoA + acetylhistone H3
-
?
additional information MOZ specifically interacts and associates with transcription factors such as AML1, PU.1, p53, Runx2 and NF-kappaB, functioning as their transcriptional coactivator and cooperatively activating target gene transcription Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Mus musculus
monocytic leukemia zinc finger protein
-
Mus musculus
More MOZ, i.e. monocytic leukemia zinc finger protein, is a Myst, i.e. MOZ, Ybf2 (Sas3), Sas2, Tip60, type histone acetyltransferase, HAT Mus musculus
MOZ
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Mus musculus

General Information

General Information Comment Organism
malfunction MOZ generates fusion genes, such as MOZ-TIF2, MOZ-CBP and MOZ-p300, in acute myeloid leukemia by chromosomal translocation leading to repressed differentiation, hyper-proliferation, and self-renewal of myeloid progenitors through deregulation of MOZ-regulated target gene expression. Roles of MOZ and MOZ fusion genes in normal and malignant hematopoiesis, mechanism, overview Mus musculus
physiological function histone acetylation is one of the major epigenetic mechanisms to regulate gene expression. MOZ is essential for the generation and maintenance of hematopoietic stem cells and for the appropriate development of myeloid, erythroid and B-lineage cell progenitors. MOZ is also required for self-renewal of hematopoietic stem cells Mus musculus