Literature summary for 2.3.1.48 extracted from

Buczek-Thomas, J.A.; Hsia, E.; Rich, C.B.; Foster, J.A.; Nugent, M.A.
Inhibition of histone acetyltransferase by glycosaminoglycans (2008), J. Cell. Biochem., 105, 108-120.

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Inhibitors

Inhibitors	Comment	Organism	Structure
chondroitin sulfate	-	Homo sapiens
heparan sulfate proteoglycans	heparan sulfate proteoglycans isolated from corneal and pulmonary fibroblasts inhibit HAT activity with similar effectiveness as heparin	Homo sapiens
heparin	ability of heparin to inhibit HAT is dependent upon its size and structure: small heparin-derived oligosaccharides (above 8 sugars) and N-desulfated or O-desulfated heparin show reduced inhibitory activity. Heparin is shown to bind to pCAF. Enzyme assays indicate that heparin shows the characteristics of a competitive-like inhibitor causing a 50fold increase in the Km of pCAF for histone H4	Homo sapiens
hyaluronic acid	-	Homo sapiens
Keratan sulfate	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0000053	-	histone H4	in the absence of heparin	Homo sapiens
0.000259	-	histone H4	in the presence of heparin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + histone	-	Homo sapiens	CoA + acetylhistone	-	?
acetyl-CoA + histone H3	-	Homo sapiens	CoA + acetylhistone H3	-	?
acetyl-CoA + histone H4	-	Homo sapiens	CoA + acetylhistone H4	-	?

Synonyms

Synonyms	Comment	Organism
HAT	-	Homo sapiens
histone acetyltransferase	-	Homo sapiens
p300/CBP-associated factor (pCAF)	representing residues 492-658	Homo sapiens

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Release 2023.1 (January 2023)