Inhibitors | Comment | Organism | Structure |
---|---|---|---|
anacardic acid | reversibly and noncompetitively inhibits HAT activity with a 50% inhibitory concentration of 0.03 nM. The parasiticidal effect of anacardic acid is at least partially associated with its inhibition of PfGCN5 HAT, resulting in the disturbance of the transcription program in the parasites | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H4 | - |
Plasmodium falciparum | CoA + acetylhistone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Plasmodium falciparum |
histone acetyltransferase | - |
Plasmodium falciparum |
PfGCN5 HAT | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.026 | - |
inhibition of recombinant PfGCN5 | Plasmodium falciparum | anacardic acid |