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Literature summary for 2.3.1.48 extracted from

  • Cui, L.; Miao, J.; Furuya, T.; Fan, Q.; Li, X.; Rathod, P.K.; Su, X.Z.; Cui, L.
    Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development (2008), Eukaryot. Cell, 7, 1200-1210.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
anacardic acid reversibly and noncompetitively inhibits HAT activity with a 50% inhibitory concentration of 0.03 nM. The parasiticidal effect of anacardic acid is at least partially associated with its inhibition of PfGCN5 HAT, resulting in the disturbance of the transcription program in the parasites Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4
-
Plasmodium falciparum CoA + acetylhistone H4
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Plasmodium falciparum
histone acetyltransferase
-
Plasmodium falciparum
PfGCN5 HAT
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.026
-
inhibition of recombinant PfGCN5 Plasmodium falciparum anacardic acid