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Literature summary for 2.3.1.48 extracted from

  • Sun, Y.; Jiang, X.; Chen, S.; Fernandes, N.; Price, B.D.
    A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM (2005), Proc. Natl. Acad. Sci. USA, 102, 13182-13187.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
bleomycin activation of the ATM-associated enzyme by bleomycin, the free, non-ATM-associated, Tip60 activity is not activated by bleomycin Homo sapiens
additional information DNA damage induces the rapid acetylation of ATM by Tip60 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and inactive mutant Tip60 in HeLa cells and 293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATM kinase + acetyl-CoA Homo sapiens ATM protein kinase regulates the cell’s response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair, suppression of Tip60 blocks the activation of ATM’s kinase activity, ATM autophosphorylation e.g. at Ser1981, and prevents the ATM-dependent phosphorylation of p53 and chk2, inactivation of Tip60 sensitizes cells to ionizing radiation, overview acetylated ATM kinase + CoA
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATM kinase + acetyl-CoA ATM protein kinase regulates the cell’s response to DNA damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA repair, suppression of Tip60 blocks the activation of ATM’s kinase activity, ATM autophosphorylation e.g. at Ser1981, and prevents the ATM-dependent phosphorylation of p53 and chk2, inactivation of Tip60 sensitizes cells to ionizing radiation, overview Homo sapiens acetylated ATM kinase + CoA
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ATM kinase + acetyl-CoA the ataxia telangiectasia mutant, i.e. ATM, protein kinase, ATM forms a stable complex with Tip60 through the conserved, highly required FATC domain of ATM, the interaction between ATM and Tip60 is not regulated in response to DNA damage, but is specifically induced by DNA damage, overview, mutations in the FATC domain that abolish the interaction between ATM and Tip60 Homo sapiens acetylated ATM kinase + CoA
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Synonyms

Synonyms Comment Organism
HAT
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Homo sapiens
Tip60
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
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assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
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Homo sapiens