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Literature summary for 2.3.1.48 extracted from

  • Ciurciu, A.; Komonyi, O.; Pankotai, T.; Boros, I.M.
    The Drosophila histone acetyltransferase Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation (2006), Mol. Cell. Biol., 26, 9413-9423.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Cloned(Commentary)

Cloned (Comment) Organism
gene dGN5, genetic crosses and phenotype analysis, overview, determination of genetic interaction of dGcn5 and dAda2a Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
E355stop site-directed mutagenesis of the Gn5 gene, inactive mutant, the loss of either dGcn5 or dAda2a function results in similar chromosome structural and developmental defects, in dAda2a mutants, the nucleosomal H4 acetylation at lysines 12 and 5 is significantly reduced, while the acetylation established by dAda2b-containing Gcn5 complexes at H3 lysines 9 and 14 is unaffected, overview Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Drosophila melanogaster 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 + acetyl-CoA Drosophila melanogaster acetylation of Lys9, and Lys14 acetyl-histone H3 + CoA
-
 ?
histone H4 + acetyl-CoA Drosophila melanogaster acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation acetyl-histone H4 + CoA
-
 ?
additional information Drosophila melanogaster the enzyme plays a role in chromatin structure and gene expression regulation as a catalytic component of multiprotein complexes, some of which also contain Ada2-type transcriptional coactivators ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 + acetyl-CoA acetylation of Lys9, and Lys14 Drosophila melanogaster acetyl-histone H3 + CoA
-
 ?
histone H4 + acetyl-CoA acetylation of Lys5, Lys8, and Lys12, Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation Drosophila melanogaster acetyl-histone H4 + CoA
-
 ?
histone H4 + acetyl-CoA acetylation of Lys5, Lys8, and Lys12 Drosophila melanogaster acetyl-histone H4 + CoA
-
 ?
additional information the enzyme plays a role in chromatin structure and gene expression regulation as a catalytic component of multiprotein complexes, some of which also contain Ada2-type transcriptional coactivators Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
Gcn5
-
 Drosophila melanogaster
HAT
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Drosophila melanogaster