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Literature summary for 2.3.1.48 extracted from

  • Park, P.H.; Lim, R.W.; Shukla, S.D.
    Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression (2005), Am. J. Physiol. Gastrointest. Liver Physiol., 289, G1124-G1136.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ethanol ethanol induces the enzyme expression in the liver and activates the enzyme at specific lysine residues, e.g. Lys9 or Lys14, mechanisms of ethanol-induced histone H3 acetylation, overview Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
analysis and mechanism of gene expression Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 + acetyl-CoA Rattus norvegicus the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview acetyl-histone H3 + CoA
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 + acetyl-CoA the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview Rattus norvegicus acetyl-histone H3 + CoA
-
?
histone H3 + acetyl-CoA acetylation at Lys9 and Lys14 Rattus norvegicus acetyl-histone H3 + CoA
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Rattus norvegicus