Literature summary for 2.3.1.48 extracted from

Cullis, P.M.; Wolfenden, R.; Cousens, L.S.; Alberts, B.M.
Inhibition of histone acetylation by N-[2-(S-coenzyme A)acetyl] spermidine amide, a multisubstrate analog (1982), J. Biol. Chem., 257, 12165-12169.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-(S-coenzyme A)hex-5-ene	-	Bos taurus
1-(S-coenzyme A)propan-2-one	-	Bos taurus
2-(S-coenzyme A)acetaldehyde	-	Bos taurus
2-(S-coenzyme A)acetic acid	-	Bos taurus
2-(S-coenzyme A)acetic acid thiophenyl ester	-	Bos taurus
N-[2-(S-Coenzyme A)acetyl]spermidine amide	strong	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + histone	-	Bos taurus	CoA + acetylhistone	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Bos taurus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.8	-	assay at	Bos taurus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00001	-	N-[2-(S-Coenzyme A)acetyl]spermidine amide	below	Bos taurus
0.000014	-	1-(S-coenzyme A)hex-5-ene	-	Bos taurus
0.0013	-	2-(S-coenzyme A)acetic acid thiophenyl ester	-	Bos taurus
0.032	-	2-(S-coenzyme A)acetic acid	-	Bos taurus

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Release 2023.1 (January 2023)