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Literature summary for 2.3.1.47 extracted from

  • Kerbarh, O.; Campopiano, D.J.; Baxter, R.L.
    Mechanism of alpha-oxoamine synthases: identification of the intermediate Claisen product in the 8-amino-7-oxononanoate synthase reaction (2006), Chem. Commun. (Camb. ), 2006, 60-62.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-carboxyhexanoyl-CoA + L-alanine Escherichia coli the enzyme catalyzes the first committed step in the four step pathway, the decarboxylative condensation of L-alanine and pimeloyl-CoA to give (7S)-8-amino-7-oxononanoate 8-amino-7-oxononanoate + CoA + CO2
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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Reaction

Reaction Comment Organism Reaction ID
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein] analysis of the reaction mechanism via an enzyme-bound intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, presence of multiple catalytic residues in the Escherichia coli enzyme Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-carboxyhexanoyl-CoA + L-alanine the enzyme catalyzes the first committed step in the four step pathway, the decarboxylative condensation of L-alanine and pimeloyl-CoA to give (7S)-8-amino-7-oxononanoate Escherichia coli 8-amino-7-oxononanoate + CoA + CO2
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?
6-carboxyhexanoyl-CoA + L-alanine a Claisen condensation Escherichia coli 8-amino-7-oxononanoate + CoA + CO2
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pimeloyl-CoA + L-alanine methyl ester trapping and determination of the reaction intermediate using the the more stable methyl ester of the substrate, overview Escherichia coli ?
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Synonyms

Synonyms Comment Organism
AONS
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Escherichia coli
More the enzyme is a member of the alpha-oxoamine synthase enzyme family Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Escherichia coli