Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-carboxyhexanoyl-CoA + L-alanine | Escherichia coli | the enzyme catalyzes the first committed step in the four step pathway, the decarboxylative condensation of L-alanine and pimeloyl-CoA to give (7S)-8-amino-7-oxononanoate | 8-amino-7-oxononanoate + CoA + CO2 | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein] | analysis of the reaction mechanism via an enzyme-bound intermediate beta-ketoacid pyridoxal-5'-phosphate aldimine, presence of multiple catalytic residues in the Escherichia coli enzyme | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-carboxyhexanoyl-CoA + L-alanine | the enzyme catalyzes the first committed step in the four step pathway, the decarboxylative condensation of L-alanine and pimeloyl-CoA to give (7S)-8-amino-7-oxononanoate | Escherichia coli | 8-amino-7-oxononanoate + CoA + CO2 | - |
? | |
6-carboxyhexanoyl-CoA + L-alanine | a Claisen condensation | Escherichia coli | 8-amino-7-oxononanoate + CoA + CO2 | - |
? | |
pimeloyl-CoA + L-alanine methyl ester | trapping and determination of the reaction intermediate using the the more stable methyl ester of the substrate, overview | Escherichia coli | ? | - |
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Synonyms | Comment | Organism |
---|---|---|
AONS | - |
Escherichia coli |
More | the enzyme is a member of the alpha-oxoamine synthase enzyme family | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Escherichia coli |