Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid | inhibition of O-acetylation in vivo through inhibition of Golgi substrate transporter proteins | Homo sapiens | |
CMP | - |
Homo sapiens | |
CoA | product inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi lumen | - |
Homo sapiens | 5796 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + CMP-N-acetylneuraminic acid | Homo sapiens | the CMP-N-acetyl-neuraminic acid and acetyl-CoA transporters are critical components for the O-acetylation of CMPNeu5Ac in Golgi lumen, with specific inhibition of either transporter leading to a reduction in the formation of CMP-5-N-acetyl-9-O-acetyl-neuraminic acid, O-acetylation in human colon Golgi vesicles is regulated by the concentration of CMP-Neu5Ac and AcCoA in the lumen, both being under the control of specific transport proteins, overview | CoA + CMP-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
additional information | Homo sapiens | 5-N-acetyl-9-O-acetyl-neuraminic acid can be transferred from neo-synthesised CMP-Neu5,9Ac2 to various endogenous glycoproteins in the same Golgi vesicles | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | mucosa | Homo sapiens | - |
colonic cancer cell | a reduction of O-acetylation is associated with the early stages of colorectal cancer | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + CMP-N-acetylneuraminic acid | - |
Homo sapiens | CoA + CMP-N-acetyl-9-O-acetyl-neuraminate | the 9-O-acetylsialic acid is the main product | ? | |
acetyl-CoA + CMP-N-acetylneuraminic acid | the CMP-N-acetyl-neuraminic acid and acetyl-CoA transporters are critical components for the O-acetylation of CMPNeu5Ac in Golgi lumen, with specific inhibition of either transporter leading to a reduction in the formation of CMP-5-N-acetyl-9-O-acetyl-neuraminic acid, O-acetylation in human colon Golgi vesicles is regulated by the concentration of CMP-Neu5Ac and AcCoA in the lumen, both being under the control of specific transport proteins, overview | Homo sapiens | CoA + CMP-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
additional information | 5-N-acetyl-9-O-acetyl-neuraminic acid can be transferred from neo-synthesised CMP-Neu5,9Ac2 to various endogenous glycoproteins in the same Golgi vesicles | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
7(9)-OAT | - |
Homo sapiens |
sialate-7(9)-O-acetyltransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |