Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein A-I | in proteoliposomes, that stimulate the enzyme activity | Homo sapiens | |
apolipoprotein E | in proteoliposomes, that stimulate the enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | cholesterol and (24S)-hydroxycholesterol compete for enzyme activity | ? | - |
? | |
phosphatidylcholine + cerebrosterol | Homo sapiens | i.e. (24S)-hydroxycholesterol | 1-acylglycerophosphocholine + cerebrosteryl ester | - |
? | |
phosphatidylcholine + cholesterol | Homo sapiens | - |
1-acylglycerophosphocholine + cholesteryl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P04180 | gene lcat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuroblastoma cell | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-(6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl)-sn-glycero-3-phosphocholine + cerebrosterol | i.e. 16:0-6:0 NBD-PC + (24S)-hydroxycholesterol | Homo sapiens | 1-palmitoyl-sn-glycero-3-phosphocholine + cerebrosteryl-(6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl)-ester | - |
? | |
additional information | cholesterol and (24S)-hydroxycholesterol compete for enzyme activity | Homo sapiens | ? | - |
? | |
phosphatidylcholine + cerebrosterol | i.e. (24S)-hydroxycholesterol | Homo sapiens | 1-acylglycerophosphocholine + cerebrosteryl ester | - |
? | |
phosphatidylcholine + cholesterol | - |
Homo sapiens | 1-acylglycerophosphocholine + cholesteryl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lecithin-cholesterol acyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells. The enzyme, in the presence of the apolipoproteins, converts (24S)-hydroxycholesterol into esters restricted to the extracellular environment, thus preventing or limiting oxysterol-induced neurotoxic injuries to neurons in culture | Homo sapiens |