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Literature summary for 2.3.1.43 extracted from

  • La Marca, V.; Spagnuolo, M.S.; Cigliano, L.; Marasco, D.; Abrescia, P.
    The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells (2014), J. Neurochem., 130, 97-108.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
apolipoprotein A-I in proteoliposomes, that stimulate the enzyme activity Homo sapiens
apolipoprotein E in proteoliposomes, that stimulate the enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cholesterol and (24S)-hydroxycholesterol compete for enzyme activity ?
-
?
phosphatidylcholine + cerebrosterol Homo sapiens i.e. (24S)-hydroxycholesterol 1-acylglycerophosphocholine + cerebrosteryl ester
-
?
phosphatidylcholine + cholesterol Homo sapiens
-
1-acylglycerophosphocholine + cholesteryl ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P04180 gene lcat
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
Homo sapiens
-
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-(6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl)-sn-glycero-3-phosphocholine + cerebrosterol i.e. 16:0-6:0 NBD-PC + (24S)-hydroxycholesterol Homo sapiens 1-palmitoyl-sn-glycero-3-phosphocholine + cerebrosteryl-(6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl)-ester
-
?
additional information cholesterol and (24S)-hydroxycholesterol compete for enzyme activity Homo sapiens ?
-
?
phosphatidylcholine + cerebrosterol i.e. (24S)-hydroxycholesterol Homo sapiens 1-acylglycerophosphocholine + cerebrosteryl ester
-
?
phosphatidylcholine + cholesterol
-
Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
?

Synonyms

Synonyms Comment Organism
lecithin-cholesterol acyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells. The enzyme, in the presence of the apolipoproteins, converts (24S)-hydroxycholesterol into esters restricted to the extracellular environment, thus preventing or limiting oxysterol-induced neurotoxic injuries to neurons in culture Homo sapiens